Folic acid

Generic name
Folic acid
Brand name
ATC Code
B03BB01
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Folic acid

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

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Megaloblastic anaemia
  • Oral
    • Term neonate
      [5]
      • 50 microg./kg/day in 1 dose
    • 1 month up to 18 years
      [5]
      • 0.5 - 1 mg/day in 1 dose
Folic acid supplements in chronic haemolysis
  • Oral
    • Term neonate
      [3]
      • 0.5 mg/dose every other day.
    • 1 month up to 1 year
      [3]
      • 0.5 mg/dose every other day.
    • 1 year up to 5 years
      [3]
      • 0.5 mg/day in 1 dose
    • 5 years up to 18 years
      [3]
      • 2.5 mg/dose 3 times a week.
Moderate to severe haemolysis resulting from spherocytosis
  • Oral
    • Term neonate
      [4]
      • 0.5 mg/day in 1 dose
    • 1 month up to 6 years
      [4]
      • 0.5 mg/day in 1 dose
    • 6 years up to 18 years
      [4]
      • 0.5 - 1 mg/day in 1 dose
Homocysteine metabolism disorders
  • Intravenous
    • Term neonate
      [2]
      • 15 mg/kg/day in 3 doses.

      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using folic acid for this indication.

    • 1 month up to 18 years
      [2]
      • 15 mg/kg/day in 3 doses.

      • Treatment by or after consultations with a paediatric specialist (metabolic disorders) who has experience using folic acid for this indication.
To reduce the side effects of methotrexate in inflammatory diseases
  • Oral
    • Term neonate
      • 5 - 10 mg/dose once a week. one or two days after administration of methotrexate.
    • 1 month up to 18 years
      • 5 - 10 mg/dose once a week. one or two days after administration of methotrexate.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

VITAMIN B12 AND FOLIC ACID

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Vitamin B12 (cyanocobalamin and analogues)
B03BA03

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Blau, Hoffmann, Leonard and Clarke, Physicians guide to the treatment and follow-up of metabolic diseases., Springer, 2006
  3. Werkgroep Benigne Kinderhematologie, Expert opinion foliumzuur suppletie bij chronische hemolyse
  4. Sectie Kinder Hemato-oncologie NVK, Richtlijn Sferocytose, www.nvk.nl, 2013
  5. Franssen MJAM et al, Werkboek Kinderhematologie, VU Uitgeverij, 2001, 2e druk
  6. AVOXA, ABDA-Datenbank Wirkstoffdossier Folsäure, Letzte Bearbeitung 04/2011, aufgerufen am 13.03.2019
  7. Hevert-Arzneimittel GmbH & Co. KG, SmPC, Folsäure Hevert 5 mg Injektionslösung (6290819.00.00), 04/13
  8. Hevert-Arzneimittel GmbH & Co. KG, SmPC, Folsäure forte Hevert Injektionslösung (6831801.00.00), 10/15
  9. Verla-Pharm Arzneimittel GmbH & Co.KG, SmPC, Folverlan® 0,4 mg Tabletten (42894.00.00), 05/16
  10. ratiopharm GmbH, SmPC, Folsäure-ratiopharm® 5 mg Tabletten (1909.99.99), 09/16
  11. Verla-Pharm Arzneimittel GmbH & Co.KG, SmPC, Folverlan® 5mg Tabletten (1909.99.99), 05/16
  12. Teofarma srl, SmPC, Folsan® 0,4 mg Tabletten (46167.00.00), 06/14
  13. Teofarma srl, SmPC, Folsan® 5 mg Tabletten (9185.00.00), 09/13
  14. TEVA GmbH, SmPC, DreisaFol® 5 mg Tabletten (1909.99.99), 09/16

Changes

Therapeutic Drug Monitoring


Overdose