Vincristine

Generic name
Vincristine
Brand name
ATC Code
L01CA02
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Vincristine

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Oncological conditions
  • Intravenous
    • 1 month up to 18 years

      • The dose and dosing frequency of cytostatic agents depend on the condition and are very much subject to new insights. Cytostatic drugs are mostly used in oncology and haematology in combinations. For this reason, please refer to the detailed treatment protocols.

        The following indicative dosages have been stated by the manufacturer:

        Children: 1.5-2.0 mg/m² once a week. The usual starting dose for children who weight 10 kg or less is 0.05 mg/kg per week

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Convulsions, often with hypertension and in a few cases followed by coma, paralytic ileus (particularly in young children), hepato-occlusive conditions 

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Extravasation: Inject hyaluronidase into the area immediately. Cover the site of the extravasation with warm compresses. Consult the cosmetic surgeon.

General cytostatic agents: a range of cytostatics can trigger hypersensitivity reactions. An emergency set (containing epinephrine, clemastine and hydrocortisone) should be present in the treatment room. The emergency set also contains specific antidotes.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Vinca alkaloids and analogues
L01CA01
Podophyllotoxin derivatives
L01CB01

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Pharmachemie BV, SPC Vincristinesulfaat PCH (RVG 10956), www.cbg-meb.nl, Geraadpleegd 28 mei 2010, http://db.cbg-meb.nl/IB-teksten/h10956.pdf

Changes

Therapeutic Drug Monitoring


Overdose