Vinblastine

Generic name
Vinblastine
Brand name
ATC Code
L01CA01
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Vinblastine

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Oncological conditions
  • Intravenous
    • 1 month up to 18 years

      • The dose and dosing frequency of cytostatic agents depend on the condition and are very much subject to new insights. Cytostatic drugs are mostly used in oncology and haematology in combinations. For this reason, please refer to the detailed treatment protocols.

        As an indication, the manufacturer gives the following dosage: start with a one-time intravenous dose of 2.5 mg/m², followed by a leukocyte count to determine the patient’s sensitivity to the drug. The starting dose in children can be increased weekly by 1.25 mg/m². The usual dose for children is 7.5 mg/m². As a monotherapy, 12.5 mg/m² is used.
        .

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Extravasation: Inject hyaluronidase into the area immediately. Cover the site of the extravasation with warm compresses. Consult the cosmetic surgeon.

General cytostatic: a range of cytostatics can trigger hypersensitivity reactions. An emergency set (containing epinephrine, clemastine and hydrocortisone) should be present in the treatment room. The emergency set also contains specific antidotes.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Vinca alkaloids and analogues
L01CA02
Podophyllotoxin derivatives
L01CB01

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Pharmachemie BV, SPC Vinblastinesulfaat (RVG 101349), www.cbg-meb.nl, Geraadpleegd 09 juli 2010, http://db.cbg-meb.nl/IB-teksten/h101349.pdf

Changes

Therapeutic Drug Monitoring


Overdose