Mercaptopurine

Generic name
Mercaptopurine
Brand name
ATC Code
L01BB02
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Mercaptopurine

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Inflammatory bowel disease (IBD)
  • Oral
    • 1 month up to 18 years
      [2]
      • 1 - 1.5 mg/kg/day in 1 dose
Oncological conditions
  • Oral
    • 0 years up to 18 years
      [3]

      • Note:
        the dose and dosing frequency of cytostatic agents depend on the condition and are very much subject to new insights. Cytostatic drugs are mostly used in oncology and haematology in combinations. For this reason, please refer to the detailed treatment protocols.

        The following indicative dosages have been stated by the manufacturer: 2.5 mg/kg/day OR 50-75 mg/m²/day

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Hypoglycaemia (especially with low BMI or children <6 years).

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ANTIMETABOLITES

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Purine analogues
L01BB03
Pyrimidine analogues
L01BC01

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Turner D, et al., Management of pediatric ulcerative colitis: joint ECCO and ESPGHAN Evidence-Based Consensus Guidelines, JPGN, 2012, 55(3), 340-61
  3. GlaxoSmithKline BV, SPC Puri-Nethol (RVG 00589) 13-2-2019, www.cbg-meb.nl
  4. Nova, SmPC Xaluprine 20mg/ml Suspension zum Einnehmen (EU/1/11/727/001), 07/2017
  5. MEDICE, SmPC Mercaptopurin 10mg Tabletten (64742.00.00), 10/2017
  6. Aspen, SmPC Puri-Nethol 50mg Tabletten (6102083.00.00), 09/2017
  7. Informatorium Medicamentorum., (Interacties), Geraadpleegd 16 aug 2018

Changes

Therapeutic Drug Monitoring


Overdose