Bleomycin

Generic name
Bleomycin
Brand name
ATC Code
L01DC01
Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Oncological conditions
  • Intravenous
    • 1 month up to 18 years

      • The dose and dosing frequency of cytostatic agents depend on the condition and are very much subject to new insights. Cytostatic drugs are mostly used in oncology and haematology in combinations. For this reason, please refer to the detailed treatment protocols; it is also the reason why no dose recommendations have been included.

Renal impaiment in children > 3 months

  • GFR ≥ 30: dose adjustment is not needed
  • GFR 10-30: 50-75% of normal reversal dose, adjustment of dosing interval is not needed.
  • GFR <10: 50% of normal reversal dose, adjustment of dosing interval is not necessary.
Clinical consequences

With impaired renal function, the clearance of bleomycin decreases. This increases the risk of toxicity.

Clinical Effects:
The most important side effect is interstitial pneumonia which occurs in approximately 10% of patients and may progress to irreversible pulmonary fibrosis. The risk of pulmonary toxicity increases with the cumulative dose. The most common side effects are (incidence up to 50%) impairment of skin and mucous membranes. Flagellate pigmentation with linear hyperpigmentation and itching (incidence 8-38%) is dose-related.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Extravasation: cooling with a cold compress is recommended.

General cytostatic: a range of cytostatics can trigger hypersensitivity reactions. An emergency set (containing epinephrine, clemastine and hydrocortisone) should be present in the treatment room. The emergency set also contains specific antidotes.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Anthracyclines and related substances
L01DB02
L01DB01

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. NKFK Workinggroup Acute Kidney Impairment, Extrapolation of KNMP risk analysis "Impaired renal function" for adults to children, 20 Dec 2021

Changes

Therapeutic Drug Monitoring


Overdose