Asparaginase

Generic name
Asparaginase
Brand name
ATC Code
L01XX02
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Asparaginase

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Oncological conditions
  • Intravenous
    • 1 month up to 18 years
      [2] [3]

      • The dose and dosing frequency of cytostatic agents depend on the condition and are very much subject to new insights. Cytostatic drugs are mostly used in oncology and haematology in combinations. For this reason, please refer to the detailed treatment protocols.


        The following dosage is mentioned as an indication by the manufacturer:
        Paronal (colaspase): 50-200 IU/kg/day or every other day for 10-28 days.
        Erwinase (crisantaspase): 25,000 IU/m² 3 times a week for 2 weeks.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Compared with children, the incidence of hepatic and pancreatic toxicities and of venous thromboembolic events may be increased in adolescents and young adults.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Extravasation: Severe reactions are not to be expected.

Watch out for allergic reactions to Paronal; in cases of hypersensitivity, switch to Erwinia asparaginase.

General cytostatic: a range of cytostatics can trigger hypersensitivity reactions. An emergency set (containing epinephrine, clemastine and hydrocortisone) should be present in the treatment room. The emergency set also contains specific antidotes.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

OTHER ANTINEOPLASTIC AGENTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Methylhydrazines
L01XB01
PROTEINEKINASEREMMERS
L01XE06
L01XE01
Other antineoplastic agents
L01XX05
L01XX24

References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Nycomed BV, SPC Paronal (RVG 16575), www.cbg-meb.nl, Geraadpleegd 26 mei 2010, http://db.cbg-meb.nl/IB-teksten/h16575.pdf
  3. EUSA Pharma SAS, SmPC Erwinase (RVG 16986) 02-02-2015, www.cbg-meb.nl

Changes

Therapeutic Drug Monitoring


Overdose