Pharmacokinetics in children

There is no information about the pharmacokinetic parameters for terbutaline in children.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Short-acting sympathomimetics are used in episodes of bronchoconstriction. As a monotherapy, they have no effect or even an unfavourable effect on the bronchial hyperreactivity. At an administration frequency higher than 3 times weekly, use should be combined with anti-inflammatory therapy.
 

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

• RESPIRATORY SYSTEM
• DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES

ADRENERGICS, INHALANTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

References

1. Bussamra MH, et al, A randomized, comparative study of formoterol and terbutaline dry powder inhalers in the treatment of mild to moderate asthma exacerbations in the pediatric acute care setting, Ann Allergy Asthma Immunol, 2009, Sep;103(3), 248-53
2. Orhan F, et al, The bronchodilatory effects of loratadine, terbutaline, and both together versus placebo in childhood asthma, J Investig Allergol Clin Immunol, 2003, 13(3), 189-92
3. Stahl E, et al, Dose response to inhaled terbutaline powder and peak inspiratory flow through Turbuhaler in children with mild to moderate asthma, Pediatr Pulmonol, 1996 , Aug;22(2), 106-10
4. Lin YZ, et al, Terbutaline nebulization and epinephrine injection in treating acute asthmatic children, Pediatr Allergy Immunol, 1996, May;7(2), 95-9
5. Kaae R, et al, Cumulative high doses of inhaled formoterol have less systemic effects in asthmatic children 6-11 years-old than cumulative high doses of inhaled terbutaline, Br J Clin Pharmacol, 2004 , Oct;58(4), 411-8
6. Drblik S, et al, Comparative efficacy of terbutaline sulphate delivered by Turbuhaler dry powder inhaler or pressurised metered dose inhaler with Nebuhaler spacer in children during an acute asthmatic episode. , Arch Dis Child. , 2003 , Apr;88(4), 319-23
7. Hancox RJ, et al , Randomised trial of an inhaled beta2 agonist, inhaled corticosteroid and their combination in the treatment of asthma, Thorax, 1999 , Jun;54(6), 482-7
8. Oldaeus G, et al, Comparison of Bricanyl Turbuhaler and Ventolin Rotahaler in children with asthma, Ann Allergy Asthma Immunol, 1995, Jan;74(1), 34-7
9. Goren A, et al, Assessment of the ability of young children to use a powder inhaler device (Turbuhaler). , Pediatr Pulmonol, 1994, Aug;18(2), 77-80
10. Phanichyakarn P, et al, A comparison of different intervals of administration of inhaled terbutaline in children with acute asthma, Asian Pac J Allergy Immunol, 1992, Dec;10(2), 89-94
11. Pedersen S, The importance of a pause between the inhalation of two puffs of terbutaline from a pressurized aerosol with a tube spacer, J Allergy Clin Immunol, 1986 , Mar;77(3), 505-9
12. Hidinger KG, et al, Childhood asthma: improved efficacy of pressurized terbutaline aerosol by use of a 750-ml spacer, Respiration, 1984, 45(2), 157-6
13. Zarkovic JP, et al, One-year safety study with bambuterol once daily and terbutaline three times daily in 2-12-year-old children with asthma. The Bambuterol Multicentre Study Group, Pediatr Pulmonol, 2000, Jun;29(6), 424-9
14. Closa RM, et al. , Efficacy of bronchodilators administered by nebulizers versus spacer devices in infants with acute wheezing, Pediatr Pulmonol, 1998 , Nov;26(5), 344-8
15. NHG, Standaard Astma bij Kinderen, Okt 2006, M24, http://nhg.artsennet.nl/kenniscentrum/k_richtlijnen/k_nhgstandaarden/Samenvattingskaartje-NHGStandaard/M24_svk.htm
16. Global Initiative for Asthma (GINA), 2020 GINA Report, Global Strategy for Asthma Management and Prevention, www.ginasthma.org, 2020

Changes

Therapeutic Drug Monitoring

Overdose