Mebendazole

Generic name
Mebendazole
Brand name
ATC Code
P02CA01
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Mebendazole

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

The absorption on an empty stomach is minimal.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Enterobiasis
  • Oral
    • 1 month up to 18 years
      [2]
      • 100 mg/dose on days 0 and 14. Repeat the course of treatment as required. .

      • Children under 2 years of age should only be treated if the infection does not recede with hygienic measures alone.
Ascariasis, trichuriasis, toxocariasis and hookworm infections
  • Oral
    • 1 month up to 18 years
      [1]
      • 200 mg/day in 2 doses.
      • Duration of treatment:

        3 days
Taenia Solium infection
  • Oral
    • 2 years up to 18 years
      [5]
      • 600 mg/day in 2 doses. During 3 consecutive days. .

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Very rare: in infants: fever, convulsions and erythema multiforme.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

There is little experience of use in children younger than 2 years.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

ANTINEMATODAL AGENTS

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Benzimidazole derivatives
P02CA03
Tetrahydropyrimidine derivatives
P02CC01
Imidazothiazole derivatives
P02CE01
Avermectines
P02CF01

References

  1. Hartwig NC, et al, Vademecum pediatrische antimicrobiele therapie, 2005
  2. Johnson&Johnson Consumer BV, SPC Vermox (RVG 06513) 08-02-2016, www.cbg-meb.nl
  3. Mediq Farma BV, SmPC Mebendazol (RVG 111026) 10-10-2017, www.geneesmiddeleninformatiebank.nl
  4. KNMP, Zelfzorgstandaard Wormen, https://www.thuisarts.nl/wormen, 2017, augustus
  5. TEVA, SmPC Mebendazol (RVG 108851) 17-12-2018, www.geneesmiddeleninformatiebank.nl

Changes

Therapeutic Drug Monitoring


Overdose