Hydrocortisone acetate 1% cutaneous (class I)

Generic name
Hydrocortisone acetate 1% cutaneous (class I)
Brand name
ATC Code
D07AA02
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Hydrocortisone acetate 1% cutaneous (class I)

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

PK data not assessed.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Atopic dermatitis
  • Cutaneous
    • 1 month up to 18 years
      [1] [2] [4]
        • Apply to the affected skin once daily according to finger-tip-unit method <insert link to FTU page).
        • Maximum dose: < 2 yrs: 30 g/week; ≥ 2 years: 60 grams/week; adults: no restriction.
        • At the start of the treatment, twice daily application for a short period can be considered
        • With improvement, taper to 1once daily dosing for 2-4 days/week.

        Note the difference between hydrocortisone acetate (class I) and hydrocortisone butyrate (class II).

         

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

With long-term, high-dose, topical application of hydrocortisone, especially under occlusion (e.g. in the diaper area), can lead to systemic side effects. [SmPC Hydrogalen]

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

In infants, the diaper may act as an occlusive dressing, increasing systemic absorption and causing systemic effects. Children have relatively large skin areas and thin skin. Prolonged use of dermatocorticosteroids on large and damaged skin areas can potentially lead to more rapid systemic side effects, adrenal suppression and also growth hormone suppression. Therefore, when long-term application is necessary, regular monitoring of height and weight is recommended.

Careful consideration is needed when applied to the eyelids because of the possibility of contaminating the conjunctiva (and the risk of glaucoma simplex or subcapsular cataracts occurring) on the one hand, and the risk of corneal damage due to the continuous rubbing/scratching of untreated eczema on the other.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

CORTICOSTEROIDS, PLAIN

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Corticosteroids, moderately potent (group II)
D07AB02
Corticosteroids, potent (group III)
D07AC01
D07AC03
D07AC17
D07AC13

References

  1. Krakowski AC, et al, Management of Atopic Dermatitis in the Pediatric Population, Pediatrics, 2008, Vol. 122 No. 4, 812-824
  2. CBO, Richtlijn Constitutioneel Eczeem, www.cbo.nl, Maart 2015
  3. NHG, Standaard constitutioneel exceem (M37), www.nhg.nl, augustus 2006
  4. Dirven-Meijer PC et al, NHG standaard Eczeem, Huisarts Wet , 2014, 57(5), 240-52
  5. Medice Pharma GmbH & Co. KG, SmPC, Soventol® Hydrocortisonacetat 0,25 %, 08/18
  6. Almirall Hermal GmbH, SmPC, Laticort® Creme 0,1 % / Laticort® Salbe 0,1 %, 08/17
  7. LEO Pharma A/S, SmPC, Alfason ®, 12/16
  8. Medice Pharma GmbH & Co. KG, SmPC, Soventol® Hydrocortisonacetat 0,5 %, 01/18
  9. Strathmann GmbH & Co. KG, SmPC, Ebenol® HCA 0,25 % Creme, 08/16
  10. INFECTOPHARM Arzneimittel, SmPC, Neuroderm® Akut 0,1% Creme , 03/18
  11. Uptodate: UpToDate®, Pediatric Drug information: Hydrocortisone topical Lexicomp® Topic 16000 Version 283.0, accessed 01/19
  12. GALENpharma GmbH, SmPC, Hydrogalen® Salbe/Creme/Lotion/Lösung 1% (34546.00.00/34546.00.01/34546.00.02/34546.00.03), 02/18
  13. Strathmann GmbH & Co. KG, SmPC, Ebenol® 0,5 % Spray 0,5g/100 ml Lösung (58937.00.00), 01/14
  14. Strathmann GmbH & Co. KG, SmPC, Ebenol® 0,25 % Creme 0,25g/100g (57573.00.00), 11/17
  15. Strathmann GmbH & Co. KG, SmPC, Ebenol® 0,5 % Creme 0,5g/100g (57573.01.00), 11/17
  16. Strathmann GmbH & Co. KG, SmPC, Ebenol® 1 % Creme 1g/100g (57573.02.00), 11/17

Changes

Therapeutic Drug Monitoring


Overdose