Desoximetasone

Generic name
Desoximetasone
Brand name
ATC Code
D07AC03
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Desoximetasone

Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Atopic dermatitis
  • Cutaneous
    • 2 years up to 18 years
      [1] [2] [4]

      • Apply to the affected skin once daily according to finger-tip-unit method.

        At the start of the treatment, twice daily application for a short period can be considered.
        If there is an improvement, reduce to once daily on 2-4 days a week.

        Maximum dose: > 2 yrs: 50 g/week; Adults: 100 g/week.

         

         

Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

In infants, the nappy can act as the enclosing dressing and thus increase the absorption. In children, inhibition of the adrenal cortex can occur fairly quickly. In addition, the secretion of growth hormone can be suppressed in them. It is therefore recommended that the height and weight should be checked regularly if prolonged use is required, as should the plasma cortisol concentration. Careful consideration is needed when applied to the eyelids because of the possibility of contaminating the conjunctiva (and the risk of glaucoma simplex or subcapsular cataracts occurring) on the one hand, and the risk of corneal damage due to the continuous rubbing/scratching of untreated eczema on the other.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

CORTICOSTEROIDS, PLAIN

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Corticosteroids, weak (group I)
D07AA02
Corticosteroids, moderately potent (group II)
D07AB02
Corticosteroids, potent (group III)
D07AC01
D07AC17
D07AC13

References

  1. Krakowski AC, et al, Management of Atopic Dermatitis in the Pediatric Population, Pediatrics, 2008, Vol. 122 No. 4, 812-824
  2. CBO, Richtlijn Constitutioneel Exceem, www.cbo.nl, Maart 2015
  3. NHG, Standaard constitutioneel exceem (M37), www.nhg.nl, augustus 2006
  4. Dirven-Meijer PC et al, NHG standaard Eczeem, Huisarts Wet, 2014, 57(5), 240-52

Changes

Therapeutic Drug Monitoring


Overdose