Betamethasone-17-valerate
Generic name
Betamethasone-17-valerate
Brand name
ATC Code
D07AC01
- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information
dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
Available formulations
No information is present at this moment.
Dosages
| Atopic dermatitis |
|---|
|
| Phimosis |
|---|
Renal impaiment in children > 3 months
No information available on dose adjustment in renal impairment.
The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Children are more sensitive than adult patients to glucocorticoid-induced suppressive action on the hypothalamic-pituitary-adrenal axis and exogenous corticosteroid effects due to the greater ratio of skin surface area to body weight.
In children who received corticosteroids externally, suppression of the hypothalamic-pituitary-adrenal axis, Cushing's syndrome, growth retardation, reduced weight gain and increase in intracranial pressure (intracranial hypertension) were observed. Suppression of the hypothalamic-pituitary-adrenal axis is manifested in children by low plasma cortisol levels and lack of response to ACTH stimulation. The increase in intracranial pressure is manifested by protuberance of the fontanel, headache and bilateral papilledema.
[SmPC DIPROSONE®]
The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Children have a relatively large skin surface and thin skin. In children long-term use on large surfaces can lead to systemic side effects, adrenal suppression and also growth hormone suppression; In long-term use on large surfaces, it is recommended to regularly check height and weight and determine the plasma cortisol level.
In infants and toddlers, the diaper can act as an occlusive dressing and thus the
increase absorption
Careful consideration is needed when applied to the eyelids because of the possibility of contaminating the conjunctiva (and the risk of glaucoma simplex or subcapsular cataracts occurring) on the one hand, and the risk of corneal damage due to the continuous rubbing/scratching of untreated eczema on the other.
Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
CORTICOSTEROIDS, PLAIN
This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.
| Corticosteroids, weak (group I) | ||
|---|---|---|
| D07AA02 | ||
| Corticosteroids, moderately potent (group II) | ||
|---|---|---|
| D07AB02 | ||
| Corticosteroids, potent (group III) | ||
|---|---|---|
| D07AC03 | ||
| D07AC17 | ||
| D07AC13 | ||
References
- Krakowski AC, et al, Management of Atopic Dermatitis in the Pediatric Population, Pediatrics, 2008, Vol. 122 No. 4, 812-824
- CBO, Richtlijn Constitutioneel Eczeem, www.cbo.nl, Maart 2015
- NHG, Standaard constitutioneel exceem (M37), www.nhg.nl, augustus 2006
- van Basten JP, et al, [The use of corticosteroid cream to treat phimosis], Ned Tijdschr Geneeskd, 2003, Aug 9;147(32), 1544-7
- GlaxoSmithKline BV, SPC Betnelan 20 december 2013, www.cbg-meb.nl
- Dirven-Meijer PC et al, NHG standaard Eczeem, Huisarts Wet, 2014, 57(5), 240-52
- Ghysel C, et al , Long-term efficiency of skin stretching and a topical corticoid cream application for unretractable foreskin and phimosis in prepubertal boys. , Urol Int. , 2009, 82(1), 81-8
Changes
Therapeutic Drug Monitoring
Overdose
