Pharmacokinetics in children

No information

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

Available formulations

No information is present at this moment.

Dosages

Constipation
Rectal 1 year up to 6 years [3] [4] 30 - 60 mg/dose, once only. 6 years up to 12 years [3] [4] 50 - 120 mg/dose, once only. 12 years up to 18 years [1] [3] [4] 120 mg/dose, once only. If the effect is insufficient, a further 120 mg can be given the same day or the next day.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Abdominal pain can occur after administration. It usually resolves after 30 minutes

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

• ALIMENTARY TRACT AND METABOLISM
• DRUGS FOR CONSTIPATION

DRUGS FOR CONSTIPATION

This pages provides a list of drugs from the same ATC class for comparison. This does not necessarily mean that these drugs are interchangeable.

Contact laxatives
	Senna Related Medicines Menu">	A06AB06

Osmotically acting laxatives
	Lactulose Related Medicines Menu">	A06AD11

Enemas
	0.9% sodium chloride Related Medicines Menu">	A06AG

References

1. Essential Pharma (M) Limited, SPC Norgalax (RVG 14141) 10-01-2019, www.geneesmiddeleninformatiebank.nl
2. Rademaker C.M.A. et al. . , Geneesmiddelen-Formularium voor Kinderen, 2008
3. Bekkali NL et al, Rectal fecal impaction treatment in childhood constipation: enemas versus high doses oral PEG, Pediatrics, 2009, Dec;124(6), e1108-15
4. Tabbers et al, Dutch Paediatric Association guideline " Obstipation in children 0-18 years", www.nvk.nl, 2015

Changes

Therapeutic Drug Monitoring

Overdose