Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Fosaprepitant

Generic name
Fosaprepitant
Brand name
ATC Code
A04AD12

Pharmacokinetics in children

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

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Available formulations

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Dosages

Prophylaxis for nausea and vomiting in chemotherapy for one-day or multi-day schedules
  • Intravenous
    • 6 months up to 18 years and ≥ 6 kg
      • Initial dose: Day 1: 3 mg/kg/dose, once only. Max: 115 mg/day.
      • Maintenance dose: Days 2 and 3: 2 mg/kg/day in 1 dose. Max: 80 mg/day.
        • run in over 30 minutes for children aged > 12 years and 60 minutes for children aged < 12.
Prophylaxis for nausea and vomiting in chemotherapy: ALTERNATIVE for one-day schedules
  • Intravenous
    • 6 months up to 2 years and ≥ 6 kg
      • 5 mg/kg/dose, once only. Max: 150 mg/dose.
        • combined with a 5-HT3 antagonist plus a corticosteroid if required.
        • Run in over 60 minutes.
    • 2 years up to 12 years
      • 4 mg/kg/dose, once only. Max: 150 mg/dose.
        • combined with a 5-HT3 antagonist plus a corticosteroid if required.
        • Run in over 60 minutes.
    • ≥ 12 years
      • 150 mg/dose, once only.
        • combined with a 5-HT3 antagonist plus a corticosteroid if required.
        • Run in over 30 minutes.

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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Reference

  1. Merck, Sharpe & Dohme BV, SmPC Ivemend (Eu/1/07/437/003) 30-07-2018, www.geneesmiddeleninformatiebank.nl

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Changes

Changes