Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Praziquantel

Generic name
Praziquantel
Brand name
ATC Code
P02BA01

Pharmacokinetics in children

No data

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

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Dosages

Infectie met S. haematobium (urogenitale bilharziasis), S. mansoni (intestinale bilharziasis) en S. intercalatum
  • Oral
    • ≥ 1 year
      [1] [6]
      • 40 mg/kg/day in 1 - 2 doses. as a single-day treatment. Repeat after 4 weeks.
      • Directions for administration:

        Oral administration should preferably be in the evening during or after a meal; if there are multiple doses per day, the interval should be 4-6 hours. In children under 6 years of age, crush the tablets (Biltricide®) and mix them with semi-solid food, or allow them to fall apart in liquid.
Infection with S. japonicum and S. mekongi
  • Oral
    • ≥ 1 year
      [1] [6]
      • 60 mg/kg/day in 1 - 3 doses. as a single-day treatment. Repeat after 4 weeks.
      • Directions for administration:

        Oral administration should preferably be in the evening during or after a meal; if there are multiple doses per day, the interval should be 4-6 hours. In children under 6 years of age, crush the tablets (Biltricide®) and mix them with semi-solid food, or allow them to fall apart in liquid.
Infectie door leverbotten (o.a. Clonorchis sinensis, Opistorchis viverrini)
  • Oral
    • ≥ 1 year
      [1] [6]
      • 75 mg/kg/day in 3 doses.
      • Duration of treatment:

        1-3 days

      • Directions for administration:

        Oral administration should preferably be in the evening during or after a meal; if there are multiple doses per day, the interval should be 4-6 hours. In children under 6 years of age, crush the tablets (Biltricide®) and mix them with semi-solid food, or allow them to fall apart in liquid.
Infection by Paragonimus westermani and other lung flukes
  • Oral
    • ≥ 1 year
      [1] [6]
      • 75 mg/kg/day in 3 doses.
      • Duration of treatment:

        1-3 days

      • Directions for administration:

        Oral administration should preferably be in the evening during or after a meal; if there are multiple doses per day, the interval should be 4-6 hours. In children under 6 years of age, crush the tablets (Biltricide®) and mix them with semi-solid food, or allow them to fall apart in liquid.
Infectie door lintwormen (o.a. Taenia saginata, Taenia solium, Hymenolepisnana, Diphyllobothrium pacificum)
  • Oral
    • 2 years up to 18 years
      [2] [7]
      • 5 - 25 mg/kg/day in 1 dose once only.
        • For Taenia saginata and Taenia solium: 5-10 mg/kg once only.
        • For Diphyllobothrium pacificum: 10 mg/kg once only.
        • For Hymenolepis nana: 15-25 mg/kg once only. Repeat treatment after 10 days if necessary.
        .
Neurocysternicose
  • Oral
    • ≥ 2 years
      [3] [8]
      • 50 mg/kg/day in 3 doses.
      • Duration of treatment:

        15 days

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. Bayer BV, SmPC Biltricide (RVG 10880) 01-08-2022, www.geneesmiddeleninformatiebank.nl
  2. Merck Serono GmbH, SmPC Cesol (Duitsland), 2015, nov.
  3. Merck Serono GmbH, SmPC Cysticide (Duitsland), 2016, feb.
  4. Uptodate: UpToDate®, Pediatric Drug information: Praziquantel Lexicomp® Version 132.0, accessed 11/18
  5. Bayer HealthCare Pharmaceuticals Inc., SmPC Biltricide® 600 mg Filmtabletten (US), 2014
  6. Bayer Vital GmbH, SmPC Biltricide® 600 mg Filmtabletten (964.00.00), 10/17
  7. Merck Serono GmbH, SmPC Cesol® 150 mg Filmtabletten (966.00.00), 11/15
  8. Merck Serono GmbH, SmPC Cysticide® 500 mg Tabletten (3943.00.01), 02/16
  9. Nederlandse Vereniging voor Parasitologie, Therapierichtlijn parasitaire infecties, https://adult.nl.antibiotica.app/sites/default/files/2020-08/NVP%20therapierichtlijn%202020.pdf, 2020

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Changes

Changes