- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
| Child | Adult | |
|---|---|---|
| Tmax | 0.75 hours | 1.2 hours |
| T½ | somewhat longer than the adult values | 6-7 hours |
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Sickle cell anaemia |
|---|
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Renal impaiment in children > 3 months
Creatinine clearance 30-60 ml/min: 50% of the dose
Creatinine clearance < 30 ml/min: do not use
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
In children, the side effect profile is similar to that in adults. However, neutropenia was more common in children aged 2–10 years, and dry skin, alopecia, headache and anemia were less common than in adults. In children aged 10–18 years, dry skin, skin ulcer, alopecia, weight gain and anemia were less common than in adults.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions
No information available on specific warnings and precautions in children.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Methylhydrazines | ||
|---|---|---|
| L01XB01 | ||
| PROTEINEKINASEREMMERS | ||
|---|---|---|
| L01XE06 | ||
| L01XE01 | ||
| Other antineoplastic agents | ||
|---|---|---|
| L01XX02 | ||
| L01XX24 | ||
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References
- Addmedica , SmPC Siklos (EU/1/07/397/002,003, 004) Rev 26; 14-10-2024, www.ema.europa.eu
- Nova Laboratories Ireland Limited, SmPC Xromi (EU/1/19/1366/001) Rev 8, 04-062024, www.ema.europa.eu
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Changes
Changes
