- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
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Available formulations
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Dosages
| Bacterial infections |
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Renal impaiment in children > 3 months
Adjustment in renal impairment as specified:
GFR 50-80 ml/min/1.73 m2
No adjustment requiredGFR 30-50 ml/min/1.73 m2
No adjustment requiredGFR 10-30 ml/min/1.73 m2
Do not administerGFR < 10 ml/min/1.73 m2
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
(Irreversible) tooth discoloration in children, tooth development disorder.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications in children
Use in children < 8 years of age, due to risk of damage to growing bone and dental tissue and irreversible discoloration (yellow/gray/brown) of teeth
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Permanent discoloration of developing teeth: Hypoplasia of tooth enamel and permanent discoloration (yellow-gray-brown) of teeth have been reported with the use of tetracyclines during the second half of pregnancy or in children up to 8 years of age. This side effect is more common with long-term use of tetracyclines, but has also been reported after repeated short-term use.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Tetracyclines | ||
|---|---|---|
| J01AA02 | ||
| J01AA08 | ||
| J01AA12 | ||
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Reference
- Pharmachemie BV, SmPC Tetracycline (RVG 50538) 17-12-2012, www.geneesmiddeleninformatiebank.nl
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Changes
Changes
