Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Niclosamide

Generic name
Niclosamide
Brand name
ATC Code
P02DA01

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

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Available formulations

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Dosages

Tapeworm (cattle, pigs, fish)
  • Oral
    • < 2 years
      [1]
      • 500 mg/dose, once only.
      • Directions for administration:
        • The daily dose must be taken in one go after breakfast.
        • The chewable tablets should be chewed into a fine paste and then swallowed with a small amount of water. The tablets can also be allowed to fall apart in water and then taken.
        • For young children, the chewable tablets should be powdered finely before administration and given with a little water.
        • It's recommended to drink sour fruit juices before the treatment with niclosamide to remove excess intestinal mucus. This way exposure of the tapeworm to the drug is enhanced.
        • It's recommended to administer laxative treatment two hours after the last dose, especially in T. Solium infections, to prevent the development of cysticercosis
    • 2 years up to 6 years
      [1]
      • 1.000 mg/day, once only.
      • Directions for administration:
        • The daily dose must be taken in one go after breakfast.
        • The chewable tablets should be chewed into a fine paste and then swallowed with a small amount of water. The tablets can also be allowed to fall apart in water and then taken.
        • For young children, the chewable tablets should be powdered finely before administration and given with a little water.
        • It's recommended to drink sour fruit juices before the treatment with niclosamide to remove excess intestinal mucus. This way exposure of the tapeworm to the drug is enhanced.
        • It's recommended to administer laxative treatment two hours after the last dose, especially in T. Solium infections, to prevent the development of cysticercosis
    • ≥ 6 years
      [1]
      • 2.000 mg/dose, once only.
      • Directions for administration:
        • The daily dose must be taken in one go after breakfast.
        • The chewable tablets should be chewed into a fine paste and then swallowed with a small amount of water. The tablets can also be allowed to fall apart in water and then taken.
        • For young children, the chewable tablets should be powdered finely before administration and given with a little water.
        • It's recommended to drink sour fruit juices before the treatment with niclosamide to remove excess intestinal mucus. This way exposure of the tapeworm to the drug is enhanced.
        • It's recommended to administer laxative treatment two hours after the last dose, especially in T. Solium infections, to prevent the development of cysticercosis
Dwarf tapeworm
  • Oral
    • < 2 years
      [1]
      • Initial dose: 500 mg/dose, once only on Day 1.
      • Maintenance dose: 250 mg/day in 1 dose Days 2 to 7.
      • Directions for administration:
        • The daily dose must be taken in one go after breakfast.
        • The chewable tablets should be chewed into a fine paste and then swallowed with a small amount of water. The tablets can also be allowed to fall apart in water and then taken.
        • For young children, the chewable tablets should be powdered finely before administration and given with a little water.
    • 2 years up to 6 years
      [1]
      • Initial dose: 1.000 mg/dose, once only on Day 1.
      • Maintenance dose: 500 mg/day in 1 dose Days 2 to 7.
      • Directions for administration:
        • The daily dose must be taken in one go after breakfast.
        • The chewable tablets should be chewed into a fine paste and then swallowed with a small amount of water. The tablets can also be allowed to fall apart in water and then taken.
        • For young children, the chewable tablets should be powdered finely before administration and given with a little water.
    • ≥ 6 years
      [1]
      • Initial dose: 2.000 mg/dose, once only on Day 1.
      • Maintenance dose: 1.000 mg/day in 1 dose Days 2 to 7.
      • Directions for administration:
        • The daily dose must be taken in one go after breakfast.
        • The chewable tablets should be chewed into a fine paste and then swallowed with a small amount of water. The tablets can also be allowed to fall apart in water and then taken.
        • For young children, the chewable tablets should be powdered finely before administration and given with a little water.

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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Reference

  1. Bayer BV, SmPC Yomesan (RVG 00886) 09-10-2011, www.geneesmiddeleninformatiebank.nl

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Changes

Changes