- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information is present at this moment.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
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Available formulations
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Dosages
| Moderate to severe pain |
|---|
|
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Renal impaiment in children > 3 months
The excretion of tramadol is slowed in patients with kidney and/or liver function disorders. Extending the dosing interval should be considered carefully for these patients, according to their needs. Do not use if the creatinine clearance is < 10 ml/min)
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Children have a higher risk of respiratory depression when using tramadol for all interventions / conditions where the airway could be obstructed in any way (FDA safety announcement 20-4-2017, Anderson et al 2017).
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Natural opium alkaloids | ||
|---|---|---|
| N02AA03 | ||
| N02AA01 | ||
| N02AA05 | ||
| N02AA59 | ||
| Phenylpiperidine derivatives | ||
|---|---|---|
| N02AB03 | ||
| N02AB03 | ||
| N02AB02 | ||
| Diphenylpropylamine derivatives | ||
|---|---|---|
| N02AC06 | ||
| N02AC03 | ||
| Oripavine derivatives | ||
|---|---|---|
| N02AE01 | ||
| Morphinan derivatives | ||
|---|---|---|
| N02AF02 | ||
| Other opioids | ||
|---|---|---|
| N02AX06 | ||
| N02AX01 | ||
| N02AX02 | ||
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References
- Grunenthal BV, SmPC Zaldiar (RVG 28113) 02-03-2017, www.geneesmiddeleninformatiebank.nl
- FDA., FDA restricts use of prescription codeine pain and cough medicines and tramadol pain medicines in children; recommends against use in breastfeeding women,, https://www.fda.gov, 2017
- Anderson BJ et al., Tramadol: keep calm and carry on., Paediatr Anaesth, 2017, Aug;27(8), 785-788
- Grunenthal BV, SmPC Zaldiar (RVG 28113) 12-12-2024, www.geneesmiddeleninformatiebank.nl
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Changes
Changes
