Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Haemofiltration fluid

Generic name
Haemofiltration fluid
Brand name
ATC Code
B05ZB

Pharmacokinetics in children

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

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Available formulations

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Dosages

Haemofiltration with normal potassium levels
  • Intravenous
    • 1 month up to 18 years
      • DUOSOL: 20-25 ml/kg/hour continuous infusion
        PHOXILIUM, PRISMASOL: 1000-4000 ml/hour/1.73 m², max. 500-3000 ml/hour

Haemofiltration with hyperkalaemia
  • Intravenous
    • 0 years up to 18 years
      • 1000-4000 ml/hour/1.73 m²

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications in children

Duosol: Hypokalaemia, metabolic alkalosis.
Acute renal failure with a pronounced hyperkatabolic status, if uraemic symptoms can no longer be corrected by haemofiltration; insufficient access to the blood hole; in cases of increased risk of bleeding as a result of systemic anticoagulation.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. B. Braun Avitum AG, SmPC Duosol met kalium (RVG 28528) 26-02-2015, www.cbg-meb.nl
  2. Gambro Lundia AB, SmPC Hemosol (RVG 23960) 21-09-2017, www.cbg-meb.nl
  3. Gambro Lundia AB, SmPC Phoxilium (RVG 101928) 21-09-2017, www.geneesmiddeleninformatiebank.nl
  4. Gambro Lundia AB, SmPC Prismasol (RVG 28877) 29-03-2018, www.geneesmiddeleninformatiebank.nl

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Changes

Changes