Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Raltegravir

Generic name
Raltegravir
Brand name
ATC Code
J05AX08

Pharmacokinetics in children

tmax = approximately 3 hours
t½ = approximately 9 hours

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Available formulations

No information is present at this moment.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Dosages

Treatment HIV infection
  • Oral
    • Film-coated tablet
      • ≥ 25 kg
        [1]
        • 800 mg/day in 2 doses.

        • NOTE: the dosage of the film-coated tablet cannot be swapped for the chewable tablet because of the different bioavailability.

    • Chewing tablet
      • ≥ 11 kg
        [1]
        • 12 mg/kg/day in 2 doses. Max: 600 mg/day. Equivalent to:
          11-14 kg: 150 mg/day in 2 doses
          14-20 kg: 200 mg/day in 2 doses
          20-28 kg: 300 mg/day in 2 doses
          28-40 kg: 400 mg/day in 2 doses
          > 40 kg:     600 mg/day in 2 doses.

        • NOTE: the dosage of the film-coated tablet cannot be swapped for the chewable tablet because of the different bioavailability.

    • Granules for oral suspension
      • ≥ 4 weeks and 3 up to 20 kg
        [1]
        • 12 mg/kg/day in 2 doses. Max: 200 mg/day.
      • 0 weeks up to 1 week
        [1]
        • 1.5 mg/kg/day in 1 dose. Max: 100 mg/day.
      • 1 week up to 4 weeks
        [1]
        • 6 mg/kg/day in 2 doses. Max: 200 mg/day.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

The frequency, type and severity of the side effects in paediatric and adolescent patients were comparable to those seen in adults.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Reference

  1. Merck Sharp & Dohme Limited, SmPC Isentress (EU/1/07/436/001-004) 25-06-2019, www.geneesmiddeleninformatiebank.nl

A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.

Changes

Changes