Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Ergocalciferol/phytomenadione/retinol/tocopherol (vitamins A/D/E/K)

Generic name
Ergocalciferol/phytomenadione/retinol/tocopherol (vitamins A/D/E/K)
Brand name
ATC Code
B05XC

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

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Available formulations

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Dosages

Supplementation of lipid-soluble vitamins
  • Intravenous
    • Term neonate
      • 1 ml/kg/day in 1 dose added to Intralipid 20%.
    • 1 month up to 18 years
      • 1 ml/kg/day in 1 dose. Max: 10 ml/day. added to Intralipid 20%.

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Per kg bodyweight, the need for vitamins is much greater in neonates than in adults. The vitamin status of the mother is not the same as the vitamin status of the neonate at birth. Transportation of fat-soluble vitamins through the placental membrane is limited. The concentrations of these vitamins are lower in neonates than in the mother. In neonates and in particular in premature infants, the lower reserves of fat-soluble vitamins should be taken into account. In the older children, there are considerable reserves of fat-soluble vitamins stocked in the body.

Young children and premature infants are more sensitive to vitamin D, resulting more quickly in overdoses with symptoms of hypercalcaemia and osteopenia.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Fresenius Kabi Nederland BV, SmPC Vitintra (RVG 16387) 17-09-2018, www.geneesmiddeleninformatiebank.nl
  3. Baxter Deutschland GmHb, SmPC Vitalipid Infant (24227.00.00), 10/2015

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Changes

Changes