Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Levocabastine, ocular application

Generic name
Levocabastine, ocular application
Brand name
ATC Code
S01GX02

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

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Available formulations

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Dosages

Allergic conjunctivitis
  • Ocular
    • 1 month up to 18 years
      • 1 drop(s)/dose 2-4x daily. in both eyes.

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. Vermeulen J, et al, Comparison of the efficacy and tolerability of topical levocabastine and sodium cromoglycate in the treatment of seasonal allergic rhinoconjunctivitis in children, Pediatr Allergy Immunol, 1994, Nov;5(4), 209-13
  2. Verin P, et al, Clinical evaluation of twice-daily emedastine 0.05% eye drops (Emadine eye drops) versus levocabastine 0.05% eye drops in patients with allergic conjunctivitis, Am J Ophthalmol, 2001, Jun;131(6), 691-8
  3. Leonardi A, et al, Clinical and biological efficacy of preservative-free NAAGA eye-drops versus levocabastine eye-drops in vernal keratoconjunctivitis patients, Br J Ophthalmol., 2007, Dec;91(12), 1662-6
  4. Whitcup SM, et al, Efficacy and tolerability of ophthalmic epinastine: a randomized, double-masked, parallel-group, active- and vehicle-controlled environmental trial in patients with seasonal allergic conjunctivitis., Clin Ther, 2004, Jan;26(1), 29-34
  5. Bauer CP, et al, Efficacy and safety of intranasally applied dimetindene maleate solution. Multicenter study in children under 14 years suffering from seasonal allergic rhinitis, Arzneimittelforschung., 2001, 51(3), 232-7
  6. Janssen-Cilag BV, SmPC Livocab (RVG 13968) 23-12-2014, www.geneesmiddeleninformatiebank.nl

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Changes

Changes