- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Available formulations
No information is present at this moment.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Dosages
| Hypertension |
|---|
|
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Renal impaiment in children > 3 months
Adjustment in renal impairment as specified:
GFR 50-80 ml/min/1.73 m2
Dose adjustment not neededGFR 30-50 ml/min/1.73 m2
50 percentage of single dose and dosing interval : 12 up to 24 uurcheck creatinine and potassium levels before starting and within 2 weeks of starting and at least once a year thereafter (depending on patient's clinical condition).
GFR 10-30 ml/min/1.73 m2
Avoid use.GFR < 10 ml/min/1.73 m2
Avoid useClinical consequences
Hyperkalemia may occur with decreased renal function. Potassium sparing agents may increase this risk. In addition, half-life and AUC of triamterene increase.
Clinical implications:
Symptoms of hyperkalemia include limb paresthesias, lethargy, confusion, weakness, paralysis, hypotension, cardiac arrhythmias (often the first clinical symptom), and heart block. The normal range of potassium in serum is given as 3.5-5.0 mmol/l. Clinically significant hyperkalemia occurs at a concentration greater than 6 mmol/l; values greater than 7-9 mmol/l are usually lethal.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
No information is present at this moment.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Cave hyperkalemia and hypokalemia.
Hyperkalemia may occur and cause cardiac arrhythmias. Check electrolytes regularly, especially if hyperkalemia is more likely. If hyperkalemia is suspected, make an ECG.
Hypokalemia may lead to arrhythmias or potentiate the action of concomitantly administered digitalis glycosides.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
| Aldosterone antagonists | ||
|---|---|---|
| C03DA01 | ||
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
References
- Heijden, van der AJ et al, Werkboek Kindernefrologie, VU Uitgeverij, 2002, 1e druk
- NKFK Workinggroup Acute Kidney Impairment, Extrapolation of KNMP risk analysis "Impaired renal function" for adults to children, 20 Dec 2021
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Changes
Changes
