- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
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Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
Geen informatie
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
Off-label
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Available formulations
Inj.vlst. (als waterstoftartraat) 5 mg/ml
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Dosages
| Hypertension |
|---|
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Hypotensie
The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Adult Side Effects
Zeer vaak (> 10%): duizeligheid. Vaak (1-10%): slaapstoornis, slaperigheid, vermoeidheid, hoofdpijn, verminderd bewustzijn, aandoeningen van het oog, dyspepsie, maag-darmstoornissen, buikpijn, oedeem, droge slijmvliezen, gewichtstoename. Verder zijn gemeld: droge mond, lusteloosheid, concentratieverlies, verlenging QT-interval, ventriculaire aritmieën ('torsade de pointes'), afname calcium- en cholesterolspiegel, toename creatininespiegel.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications in adults
Bradycardie met hartslag < 50/min. Tweede- of derdegraads AV-blok. Sick-sinussyndroom. Aanhoudende ventriculaire tachycardie of ventrikelfibrilleren. Hartritmestoornissen in de anamnese. Hypokaliëmie, hypomagnesiëmie. Verlengd QT-interval of aangeboren verlengd QT-interval in de familie.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Cave hypovolaemie.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Alerts And Precautions Adults
Vóór behandeling ECG maken en binnen de eerste 24 uur na starten van de behandeling nogmaals. Als tijdens de behandeling een verlenging van het QT-interval optreedt, voortzetting van de behandeling heroverwegen. Controle van de kaliumspiegel is aangewezen bij chronisch gebruik van corticosteroïden, laxantia of diuretica. Bij optreden van hypokaliëmie de behandeling onderbreken. Bij bestaande hypovolemie kan na parenterale toediening voorbijgaand hypotensie ontstaan. Na de eerste dosis kan het reactie- en concentratievermogen verminderd zijn. Bij pre-eclampsie en HELLP-syndroom dient de behandeling gezien de zeer hoge bloeddruk en de noodzaak van foetale bewaking (CTG) klinisch plaats te vinden. Een plotselinge te sterke daling van de bloeddruk kan een achteruitgang in de uteroplacentaire doorbloeding veroorzaken en daarmee foetale stress. Bij comedicatie van diuretica en antihypertensiva dient ECG-monitoring plaats te vinden.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Antihypertensives for pulmonary arterial hypertension | ||
|---|---|---|
| C02KX02 | ||
| C02KX01 | ||
| C02KX04 | ||
| C02KX05 | ||
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Reference
- Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
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Changes
Changes
