- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
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Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
There is only a single pharmacokinetic study known in children. That study shows that the elimination half-life in children is 2.5-6.7 hours (N = 13, ages 4 to 22 years). The therapeutic plasma concentration is 2-5 mg/l.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Brugada syndrome |
|---|
|
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Conduction disorders, extension of the QTc interval, bradycardia, hypotension, gastrointestinal problems, hypersensitivity reaction (fever, vision disorders haematological abnormalities), tinnitus.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications in children
In class I G6PD deficiency, haemolytic reactions may possibly occur (Dutch Association for Paediatric Medicine (NVK) haematology workbook)
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Adjust the dosage under ECG monitoring; have the serum levels measured if necessary. Hypokalaemia should be corrected beforehand. Because of the risk of hypersensitivity reactions, a test dose is often given first.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Antiarrhythmics, class Ia | ||
|---|---|---|
| C01BA02 | ||
| Antiarrhythmics, class Ic | ||
|---|---|---|
| C01BC04 | ||
| C01BC03 | ||
| Antiarrhythmics, class III | ||
|---|---|---|
| C01BD01 | ||
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References
- Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
- Szefler SJ, et al., Rapid elimination of quinidine in pediatric patients., Pediatrics, 1982, 70, 370-5
- Baruteau AE et al, Quinidine therapy in children affected by Brugada syndrome: are we far from a safe alternative? , Cardiol Young, 2009, Dec;19(6), 652-4
- Mehrotra S et al., Successful use of quinine in the treatment of electrical storm in a child with Brugada syndrome, J Cardiovasc Electrophysiol, 2011, May;22(5), 594-7
- NVK, Werkboek kinderhematologie, www.hematologienederland.nl/werkboek-kinderhematologie, Geraadpleegd 07 Aug 2015
- Baruteau AE et al, Quinidine therapy in children affected by Brugada syndrome: are we far from a safe alternative?, Cardiol Young, 2009, Dec;19(6), 652-4
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Changes
Changes
