- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
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Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
T½ intravasal: 17 hours.
Note: the intravasal half-life is not the same as the biological half-life (relationship between duration of the effect and time). After 3 hours, the volume-increasing effect has decreased by 50%.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Hypovolaemia with proven hypoalbuminaemia as a comorbidity |
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| Severe neonatal hyperbilirubinaemia |
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Renal impaiment in children > 3 months
No information available on dose adjustment in renal impairment.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Overfilling, hypersensitivity reactions (urticaria, anaphylaxis, fever), haemodilution (extended bleeding time at high concentrations) and renal function disorders (at high concentrations).
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Be aware of the potential for overfilling: pulmonary oedema and congestive heart failure.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Blood substitutes and plasma protein fractions | ||
|---|---|---|
| B05AA06 | ||
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References
- Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
- Nederlandse Vereniging voor Kindergeneeskunde, Richtlijn preventie, diagnostiek en behandeling van hyperbilirubinemie bij de pasgeborene, geboren na een zwangerschapsduur van meer dan 35 weken., www.nvk.nl, 2008
- CSL Behring GmbH, SmPC Alburex (RVG 105900) 27-02-2013, Geraadpleegd 06 okt 2014
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Changes
Changes
