- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Fungal infection |
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Renal impaiment in children > 3 months
Adjustment in renal impairment as specified:
GFR 50-80 ml/min/1.73 m2
Dose adjustment not neededGFR 30-50 ml/min/1.73 m2
50 percentage of single dose and dosing interval : 24 uurGFR 10-30 ml/min/1.73 m2
50 percentage of single dose and dosing interval : 24 uurGFR < 10 ml/min/1.73 m2
A general recommendation is not providedClinical consequences
With impaired renal function, the half-life of terbinafine is prolonged. This may possibly increase the risk of adverse reactions.
Clinical effects:
The clinical relevance of the longer half-life is not clear.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
No information is present at this moment.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions
No information available on specific warnings and precautions in children.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Antifungals for systemic use | ||
|---|---|---|
| D01BA01 | ||
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References
- Hartwig NC, et al, Vademecum pediatrische antimicrobiële therapie, 2005
- Mylan BV, SPC Terbinafine tabletten (RVG 28796) 18-07-2018, www.geneesmiddeleninformatiebank.nl
- AbZ-Pharma GmbH, SmPC Terbinafin AbZ 250 mg Tabletten (61642.00.00), 06/2014
- NKFK Workinggroup Acute Kidney Impairment, Extrapolation of KNMP risk analysis "Impaired renal function" for adults to children, 20 Dec 2021
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Changes
Changes
