- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
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Available formulations
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Dosages
| Oncological conditions |
|---|
|
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Extravasation: Severe necrosis. Ice compresses for the pain. Discuss excision with a plastic surgeon in cases of severe reactions.
General cytostatic: a range of cytostatics can trigger hypersensitivity reactions. An emergency set (containing epinephrine, clemastine and hydrocortisone) should be present in the treatment room. The emergency set also contains specific antidotes.
The urine is coloured orange.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Methylhydrazines | ||
|---|---|---|
| L01XB01 | ||
| MONOKLONALE ANTILICHAMEN | ||
|---|---|---|
| L01XC11 | ||
| L01XC18 | ||
| L01XC18 | ||
| Other antineoplastic agents | ||
|---|---|---|
| L01XX02 | ||
| L01XX05 | ||
| L01XX23 | ||
| L01XX24 | ||
| L01XX14 | ||
| Proteasome inhibitors | ||
|---|---|---|
| L01XG01 | ||
| Antineoplastic cell and gene therapy | ||
|---|---|---|
| L01XL04 | ||
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Reference
- Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
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Changes
Changes
