- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
The volume of distribution is greater in neonates than in older children. For the same dose in neonates and in older children, the concentration at the myoneural junction will be lower in neonates.
Elimination is independent of hepatic and renal function.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Neuromuscular blockade |
|---|
|
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Histamine release.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications in children
Mastocytosis (mast cell activation syndrome)
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Monitor neuromuscular function. The duration of action for muscle relaxants is so variable that relaxation measurement should be considered before extubation and antagonized if necessary.
Cross hypersensitivity - including from other groups - is possible. This may be based on the excipients but also on the active ingredient. Advice is to consult a pediatric allergist in case of a suspected allergic reaction to a muscle relaxant and with the request to also test for safety of alternative muscle relaxants.
Use caution in cases of (suspected) increased sensitivity to histamine release based on history
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Choline derivatives | ||
|---|---|---|
| M03AB01 | ||
| Other quaternary ammonium compounds | ||
|---|---|---|
| M03AC03 | ||
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References
- Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
- Aspen Pharma Trading Limited, SmPC Tracrium (RVG 09981) 25-07-2017, www.geneesmiddeleninformatiebank.nl
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Changes
Changes
