Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Glycine

Generic name
Glycine
Brand name
ATC Code
B05CX03

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

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Available formulations

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Dosages

Isovaleric acidaemia
  • Oral
    • 0 years up to 18 years
      • 150 - 300 mg/kg/day in 3 doses.
      • With checks of the plasma glycine levels, target value 200-400 microM

    • 0 years up to 18 years
      [2]
      • 150 - 300 mg/kg/day in 3 doses.
      • With checks of the plasma glycine levels, target value 200-400 microM

Endoresection
  • Urethral
    • 1 month up to 18 years
      • Administer during endoresection.

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Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Sodium benzoate for tackling secondary hyperammonaemia is contraindicated in organic acid disorders. Patients with organic acid disorders have a tendency to develop hypokalaemia. Potassium levels must only be corrected if there is diuresis.
Caution is needed in severe cardiopulmonary and renal conditions and impaired liver function.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Blau, Hoffmann, Leonard and Clarke, Physicians guide to the treatment and follow-up of metabolic diseases., Springer, 2006

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Changes

Changes