- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Hyperthyroidism |
|---|
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Side effects mainly occur in the first 3 months of therapy.
Agranulocytosis, neutropenia, myositis, myalgia, arthralgia, skin rashes and impaired liver function (cholestasis). Severe skin hypersensitivity reactions, such as generalized dermatitis including Stevens-Johnson syndrome, have been reported very rarely in children and adolescents (SmPC, Rivkees 2010). The side effects are dose-dependent (Minamitani 2017).
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
If pruritus / rash is moderate, antihistamines can be administered. Dose reduction or stop of therapy in case of other side effects. (Kahaly, GJ, et al. 2018). Switching to propylthiouracil is not recommended. If inevitable due to thyrotoxicosis, use only for a very short time.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Thiouracils | ||
|---|---|---|
| H03BA02 | ||
| Sulfur-containing imidazole derivatives | ||
|---|---|---|
| H03BB01 | ||
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References
- Noordam C et al, Werkboek Kinderendocrinologie, digitale publicatie op www.nvk.nl (alleen leden), 2010
- Teva Nederland BV. , DHPC Carbizol-Thiamazol 31-01-2019
- Aspen Pharma Trading Limited., SmPC Strumazol (RVG 02224) 15-02-2019, www.geneesmiddeleninformatiebank.nl
- Minamitani, K, et al, Guidelines for the treatment of childhood-onset Graves’ disease in Japan, 2016, Clin Pediatr Endocrinol, 2017, 26(2), 29-62
- Kahaly, GJ, et al, European Thyroid Association Guideline for the Management of Graves’ Hyperthyroidism, Eur Thyroid J, 2018, 7, 167–186
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Changes
Changes
