Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Pamidronic acid

Generic name
Pamidronic acid
Brand name
ATC Code
M05BA03

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

No information is present at this moment.

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Dosages

Chronic or non-severe symptomatic hypercalcaemia
  • Intravenous
    • 1 month up to 18 years
      • 0.5 - 1 mg/kg/dose in 4 hours, 2-3 days in a row, repeat every 6-8 weeks.
    • 1 month up to 18 years
      • 0.5 - 1 mg/kg/dose in 4 hours, 2-3 days in a row, repeat every 6-8 weeks.

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Because pamidronic acid binds to bone tissue, it can disrupt bone scintigraphy.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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Bisphosphonates
M05BA04
M05BA07
Other drugs affecting bone structure and mineralization
M05BX05
M05BX04

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References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Noordam C et al, Werkboek Kinderendocrinologie, digitale publicatie op www.nvk.nl (alleen leden), 2010
  3. medac, SmPC Pamifos 3mg/ml Konzentrat zur Herstellung einer Infusionslösung (59200.00.00), 11/2015
  4. Hexal, SmPC Pamidron 15mg/ml Konzentrat zur Herstellung einer Infusionslösung (58750.00.00), 11/2016
  5. ribosepharm, SmPC Ribodronat 3mg/ml Konzentrat zur Herstellung einer Infusionslösung (61521.00.00), 02/2017

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Changes

Changes