- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
The following pharmacokinetic parameters were determined in children (>5 kg):
| Atovaquon | Proguanil | |
| Vd (l/kg) | 8,8 | 20 - 79 |
| T1/2 (h) | 24 - 48 | 12 - 15 |
| Cl (l/h) | 0,5 - 6,3 | 8,7 - 64 |
The Clearance after oral intake of atovaquone and proguanil increases with increasing body weight and is approximately 70% higher in a 40 kg person than in a 20 kg person.
[SmPC Malarone® Junior Filmtabletten 62,5 mg/25 mg]
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Available formulations
No information is present at this moment.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Dosages
| Prophylaxis for malaria |
|---|
|
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Renal impaiment in children > 3 months
Adjustment in renal impairment as specified:
GFR 50-80 ml/min/1.73 m2
100 percentage of single dose and dosing interval : 24 uurWhen used prophylactically
GFR 30-50 ml/min/1.73 m2
100 percentage of single dose and dosing interval : 24 uurWhen used prophylactically
GFR 10-30 ml/min/1.73 m2
Do not administerWhen used prophylactically
GFR < 10 ml/min/1.73 m2
Do not administerWhen used prophylactically
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
No information is present at this moment.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications in children
Contraindicated for prophylactic use in severely reduced renal function (creatinine clearance < 30 ml/min).
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
In the event of vomiting within one hour after intake, give a new dose.
The tablet or tablets should preferably be taken at the same time every day, in their entirety with food or a dairy beverage. Malarone Junior should preferably be taken whole; in cases of swallowing problems in younger children, the tablets can be crushed right before intake and taken with food.
If no food can be tolerated, the tablets can also be taken without food; the systemic exposure to atovaquone is then decreased by a factor of 2-3.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
| Aminoquinolines | ||
|---|---|---|
| P01BA01 | ||
| P01BA02 | ||
| Biguanides | ||
|---|---|---|
| P01BB01 | ||
| Methanolquinolines | ||
|---|---|---|
| P01BC02 | ||
| P01BC01 | ||
| Diaminopyrimidines | ||
|---|---|---|
| P01BD01 | ||
| Artemisinin and derivatives, plain | ||
|---|---|---|
| P01BE03 | ||
| Artemisinin and derivatives, combinations | ||
|---|---|---|
| P01BF01 | ||
| P01BF05 | ||
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
References
- Hartwig NC, et al, Vademecum pediatrische antimicrobiele therapie, 2005
- GlaxoSmithKline BV, SPC Malarone Junior (RVG 28319) en Malarone (RVG 25386) 28-03-2016, www.geneesmiddeleninformatiebank.nl
- LCR, Malariabulletin , April 2024
- LCR, Malariabulletin, April 2024
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Changes
Changes
