- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No detectable amounts of ketoconazole in the serum in children aged < 1 year [Brodell 1998]
After topical application, the serum concentration of ketoconazole is 1-2% of the serum concentration for systemic administration. Percutaneous absorption is minimal and peaks after 2-3 hours. There is no accumulation in the plasma. [Taieb 1990]
In infants aged 1-5 months with seborrhagic dermatitis, plasma concentrations of up to 0.133 mg/l have been measured [SPC of Nizoral]
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Available formulations
No information is present at this moment.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Dosages
| Fungal infection van the skin, seborrhoeic dermatitis |
|---|
|
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Renal impaiment in children > 3 months
No information available on dose adjustment in renal impairment.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Burning sensation, erythema, itching, contact dermatitis, eye irritation (for the shampoo)
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions
No information available on specific warnings and precautions in children.
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
| Antibiotics | ||
|---|---|---|
| D01AA01 | ||
| Imidazole and triazole derivatives | ||
|---|---|---|
| D01AC01 | ||
| D01AC02 | ||
| D01AC20 | ||
| D01AC09 | ||
| Other antifungals for topical use | ||
|---|---|---|
| D01AE14 | ||
| D01AE13 | ||
| D01AE15 | ||
| IMIDAZOLE AND TRIAZOLE DERIVATIVES | ||
|---|---|---|
| D01AC01 | ||
| D01AC02 | ||
| D01AC20 | ||
| D01AC09 | ||
| OTHER ANTIFUNGALS FOR TOPICAL USE | ||
|---|---|---|
| D01AE14 | ||
| D01AE13 | ||
| D01AE15 | ||
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
References
- Sheffield RC, et al, Clinical inquiries. What's the best treatment for cradle cap?, J Fam Pract, 2007, Mar;56(3), 232-3
- Taieb A, et al, Topical ketoconazole for infantile seborrhoeic dermatitis, Dermatologica, 1990, 181(1), 26-32
- Cohen S, Should we treat infantile seborrhoeic dermatitis with topical antifungals or topical steroids?, Arch Dis Child, 2004, Mar;89(3), 288-9
- Brodell RT, et al, The safety of ketoconazole shampoo for infantile seborrheic dermatitis, Pediatr Dermatol, 1998, Sep-Oct;15(5), 406-7
- Nederlands Huisartsen Genootschap (NHG), NHG Standaard Dermatomycosen, https://richtlijnen.nhg.org/standaarden/dermatomycosen#samenvatting-richtlijnen-beleid, 2022 (feb)
- EurimPharm Arzneimittel GmbH, SmPC Fungoral 2% Creme (62088.00.00), 09/15
- Uptodate: UpToDate®, Pediatric Drug information: Ketoconazole topical Topic 16005 Version 146.0, accessed 03/19
- Dermapharm AG, SmPC, Ketozolin 2% Shampoo (86873.00.00), 01/18
- Hexal AG, SmPC, Ket ® med 20 mg/g Shampoo (63006.00.00), 09/16
- Johnson & Johnson GmbH, SmPC, Terzolin 2 % Creme (15003.00.00), 09/15
- Johnson & Johnson GmbH, SmPC, Nizoral 2 % Creme (1585.00.01), 09/15
- STADA GmbH, SmPC, Terzolin® 2% Lösung zur Anwendung auf der Kopfhaut (15921.00.00), 01/19
A second drug has not been selected yet.
Press ‘drugs’ followed with and select second drug from list to add the second drug to the comparison.
Changes
Changes
