Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Benzoyl peroxide

Generic name
Benzoyl peroxide
Brand name
ATC Code
D10AE01

Pharmacokinetics in children

There is no kinetic data known for children. Human research in adults has shown that the concentration of benzoic acid in the plasma after applying benzoyl peroxide gel to the skin is negligible.

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

No information is present at this moment.

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Dosages

Acne vulgaris with blackheads and inflammation symptoms
  • Cutaneous
    • 10 years up to 18 years
      [1] [2] [3] [4]
      • 5%: apply once or twice daily

      • Apply preferably in the evening to avoid contact with sunlight

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Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Dryness, erythema, itching, flaking, contact eczema. Side effects decrease when used for a longer period of time.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Side effects decrease when used for a longer period of time. Hair, textiles and metals can be bleached by benzoyl peroxide

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. Krakowski AC, et al, Practical considerations in acne treatment and the clinical impact of topical combination therapy, Pediatr Dermatol, 2008 , Jun;25 Suppl 1, 1-14
  2. Ozolins M et al, Comparison of five antimicrobial regimens for treatment of mild to moderate inflammatory facial acne vulgaris in the community: randomised controlled trial., Lancet. , 2004, Dec 18-31; 364(9452):.., 2188-95
  3. Sagransky M, Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris, Expert Opin Pharmacother , 2009, Oct;10(15), 2555-62
  4. Bruinsma M, et al, NHG Standaard Acne (derde herziening), 2017 (april)

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Changes

Changes