Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Oral rehydration solution (ORS)

Generic name
Oral rehydration solution (ORS)
Brand name
ATC Code
A07CA

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

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Available formulations

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Dosages

Rehydration
  • Oral
    • 0 years up to 18 years
      [3] [4] [5]
      • 20 ml/kg/hour until appropriate rehydration has been achieved.

           .
      • Directions for administration:

        Frequent small amounts – with a spoon – more easily accepted and less prone to cause vomiting than large quantities at once. After rehydration, supplementary to the diet and for as long as the diarrhoea remains watery, ORS is given to compensate for losses of water and electrolytes.

         

      • Alternative dosing regimen: based on the dehydration percentage:
        Mild/moderate (< 10%): 50 ml/kg in 4-6 hours or until appropriate rehydration has been achieved
        Severe (> 10%): 100 ml/kg in 4-6 hours or until appropriate rehydration has been achieved

        Choose ORS with low osmolarity (< 270 mOsm/l, Na < 75 mmol/l)

         

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Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Diarrheal illnesses with and without vomiting can lead to impaired consciousness and shock in infants and toddlers within a few hours (infant toxicosis). Home treatment of infants and small toddlers must therefore always be carried out under medical supervision. Breast-fed children should also continue to be breast-fed ad libitum during the entire rehydration phase.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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INTESTINAL ANTIINFECTIVES
A07AA02
A07AA06
A07AA09
INTESTINAL ADSORBENTS
A07BA01

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References

  1. Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
  2. Kneepkens CMF et al, Werkboek Kindergastro-Enterologie, VU Uitgeverij, 2002, 2e druk
  3. De Kruijff, C et al, Evidence-based richtlijnen voor 5 acute problemen in de Kindergeneeskunde, www.nvk.nl, 2013, Feb
  4. Gebro, SmPC Normolyt für Kinder lösl. Plv. (1-18775), 06/2014
  5. Gebro, SmPC Normhydral lösl. Plv. (1-21601), 05/2014

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Changes

Changes