- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Therapy-resistant obstipation |
|---|
|
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Inhalation, reflux or choking can cause lipoid pneumonia.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Watch out for inhalation by choking: lipoid pneumonitis. In prolonged use, check vitamins A, D and E (supplement if necessary) and check the blood clotting.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Contact laxatives | ||
|---|---|---|
| A06AB02 | ||
| A06AB08 | ||
| A06AB06 | ||
| A06AB06 | ||
| A06AB58 | ||
| Bulk-forming laxatives | ||
|---|---|---|
| A06AC01 | ||
| Osmotically acting laxatives | ||
|---|---|---|
| A06AD12 | ||
| A06AD11 | ||
| A06AD65 | ||
| A06AD65 | ||
| A06AD15 | ||
| A06AD65 | ||
| Enemas | ||
|---|---|---|
| A06AG | ||
| A06AG10 | ||
| A06AG10 | ||
| A06AG04 | ||
| A06AG11 | ||
| A06AG01 | ||
| Other drugs for constipation | ||
|---|---|---|
| A06AX01 | ||
| A06AX02 | ||
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References
- Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
- Kneepkens CMF, et al, Werkboek Kindergastro-enterologie, 2014, Derde druk
- Nederlandse Vereniging voor Kindergeneeskunde, Richtlijn Obstipatie bij kinderen 0-18 jaar, 2015
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Changes
Changes
