- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No pharmacokinetic data known for children.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
No information is present at this moment.
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Available formulations
No information is present at this moment.
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Dosages
| Constipation |
|---|
|
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Renal impaiment in children > 3 months
GFR ≥10 ml/min/1.73m2: Dose adjustment not required.
GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects in children
Abdominal pain, abdominal cramps. If young children ingest so much that diarrhoea occurs, severe rashes and blisters can occur in the perianal area. The risk of this side effect occurring is greater in children who are not yet toilet-trained.
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Prolonged use is not recommended because of permanent damage to the mucosa of the colon, such as melanosis coli. Another risk is that irreversible damage to the intestinal myenteric plexus can occur, which can negatively affect motility. This risk arises in particular with prolonged use, so it is recommended that use should be limited to a maximum of 5 days.
Few studies have been conducted into the effectiveness and side effects of “other laxatives”, including senna. As they are rarely used in practice and because of the lack of evidence, they are not recommended as a first choice.
X-Praep syrup contains 5.24% alcohol.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Softeners, emollients | ||
|---|---|---|
| A06AA01 | ||
| Contact laxatives | ||
|---|---|---|
| A06AB02 | ||
| A06AB08 | ||
| A06AB06 | ||
| A06AB58 | ||
| Bulk-forming laxatives | ||
|---|---|---|
| A06AC01 | ||
| Osmotically acting laxatives | ||
|---|---|---|
| A06AD12 | ||
| A06AD11 | ||
| A06AD65 | ||
| A06AD65 | ||
| A06AD15 | ||
| A06AD65 | ||
| Enemas | ||
|---|---|---|
| A06AG | ||
| A06AG10 | ||
| A06AG10 | ||
| A06AG04 | ||
| A06AG11 | ||
| A06AG01 | ||
| Other drugs for constipation | ||
|---|---|---|
| A06AX01 | ||
| A06AX02 | ||
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References
- Rademaker C.M.A. et al, Geneesmiddelen-Formularium voor Kinderen, 2007
- Centraal BegeleidingsOrgaan (CBO), Richtlijn Obstipatie bij kinderen van 0-18 jaar, 2009, Geraadpleegd 15 april 2013, http://www.cbo.nl/Downloads/957/rl_obstipat_10.pdf
- Meda Pharma BV, SPC X-Praep RVG 07207, www.cbg-meb.nl, Geraadpleegd 15 april 2013, http://db.cbg-meb.nl/IB-teksten/h07207.pdf
- Spiller HA, et al., Skin breakdown and blisters from senna-containing laxatives in young children, Ann Pharmacother, 2003, May;37(5), 636-9
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Changes
Changes
