Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Flunarizine

Generic name
Flunarizine
Brand name
ATC Code
N07CA03

Pharmacokinetics in children

No information

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

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Available formulations

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Dosages

Migraine prophylaxis
  • Oral
    • 15 up to 40 kg
      • 5 mg/day in 1 dose
    • ≥ 40 kg
      • 5 - 10 mg/day in 1 dose

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Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

No information is present at this moment.

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. Boccia G, et al, Functional gastrointestinal disorders in migrainous children: efficacy of flunarizine, Cephalalgia, 2006, Oct;26(10), 1214-9
  2. Caers LI, et al, Flunarizine, a calcium-entry blocker, in childhood migraine, epilepsy, and alternating hemiplegia, Clin Neuropharmacol, 1987, Apr;10(2), 162-8
  3. Guidetti V, et al, Flunarizine and migraine in childhood. An evaluation of endocrine function, Cephalalgia, 1987, Dec;7(4), 263-6
  4. Holmes B, et al, Flunarizine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use, Drugs, 1984, Jan;27(1), 6-44
  5. Lastra Martinez L, et al, [Flunarizine and dihydroergotamine in the treatment of migraine in children], An Esp Pediatr., 1990, Mar;32(3), 213-8
  6. Pothmann R., [Prevention of migraine with flunarizine and acetylsalicylic acid. A double-blind study], Monatsschr Kinderheilkd., 1987, Sep;135(9), 646-9
  7. Sorge F, et al, Flunarizine in prophylaxis of childhood migraine. A double-blind, placebo-controlled, crossover study, Cephalalgia, 1988, Mar;8(1), 1-6
  8. Visudtibhan A, et al, Flunarizine for prophylactic treatment of childhood migraine, J Med Assoc Thai, 2004, Dec;87(12), 1466-70

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Changes

Changes