Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Deflazacort

Generic name
Deflazacort
Brand name
ATC Code
H02AB13

Pharmacokinetics in children

No pharmacokinetic data in children available (SmPC)

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

No information is present at this moment.

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Available formulations

No information is present at this moment.

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Dosages

Inflammatory diseases, endocrinologic diseases, neoplastic diseases
  • Oral
    • 6 years up to 18 years and ≥ 24 kg
      • (Deflazacort) 0.25 - 1.5 mg/kg/day in 1 dose. Max: 90 mg/day.
      • If sufficient response is achieved gradually reduce dosage to lowest possible maintenance dosage.

Duchenne muscular dystrofia (DMD)
  • Oral
    • 2 years up to 18 years
      • 0.9 mg/kg/day in 1 dose

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Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects in children

Growth retardation, cerebral pseudotumor, acute pancreatitis, posterior subcapsular cataract, idiopathic intracranial hypertension. [SmPC Calcort]

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

Long-term use in children can cause  growth- and developmental delay.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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Reference

  1. Vital Pharma Nordic ApS, SmPC Deflazacort (RVG 124419) 19-01-2024, www.geneesmiddeleninformatiebank.nl

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Changes

Changes