Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Casirivimab + imdevimab

Generic name
Casirivimab + imdevimab
Brand name
ATC Code
J06BD07

Pharmacokinetics in children

No information is present at this moment.

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

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Available formulations

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Dosages

Pre-exposure prophylaxis COVID-19
  • Intravenous
    • ≥ 12 years and ≥ 40 kg

      • 600 mg/ 600 mg casirivimab / Imdevimab once. Then as needed 300 mg/ 300 mg casirivimab / imdevimab 1x every 4 weeks until prophylaxis is no longer needed.

         

      • If intravenous administration is not possible, subcutaneous administration may be considered. 

    • ≥ 12 years and ≥ 40 kg

      • 600 mg/ 600 mg casirivimab / Imdevimab once. Then as needed 300 mg/ 300 mg casirivimab / imdevimab 1x every 4 weeks until prophylaxis is no longer needed.

         

      • If intravenous administration is not possible, subcutaneous administration may be considered. 
Post-exposure prophylaxis COVID-19
  • Intravenous
    • ≥ 12 years and ≥ 40 kg
      [1]

      • 600 mg/ 600 mg casirivimab / imdevimab once as soon as possible after contact with an infected person.

      • If intravenous administration is not possible, subcutaneous administration may be considered. 

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Renal impaiment in children > 3 months

GFR ≥10 ml/min/1.73m2: Dose adjustment not required.

GFR <10 ml/min/1.73m2: A general recommendation on dose adjustment cannot be provided.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions

No information available on specific warnings and precautions in children.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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Immunoglobulins, normal human
J06BA02
J06BA01
Specific immunoglobulins
J06BB01
J06BB04
J06BB02
J06BB03
Antibacterial monoclonal antibodies
J06BC03
IMMUNOGLOBULINS, NORMAL HUMAN
J06BA02
J06BA01
Antiviral monoclonal antibodies
J06BD08
J06BD01

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Reference

  1. Roche Registration GmbH, SmPC Ronapreve (EU/1/21/1601/001) 19-11-2021, www.ema.europa.eu

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Changes

Changes