Dosages
Side effects in children
Warnings & precautions in children
Contra-indications in children

Interactions
PK
Renal impairment
References

Prednison

Generic name
Prednison
Brand name
ATC Code
H02AB07

Pharmacokinetics in children

No information is present at this moment.

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dose recommendation of formulary compared to licensed use (on-label versus off-label)

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Available formulations

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Dosages

Various rheumatological, pulmonary, gastrointestinal, haematological, nephrological, endocrinological, oncological, neurological, ocular and dermatological disorders, as well as severe allergic reactions, organ transplantation and prophylaxis of nausea and vomiting due to high-emetogenic chemotherapy
  • Oral
    • 0 years up to 18 years
      [2]
      • The dosage strongly depends on the nature and severity of the condition.

        HIGH DOSE:  2-3 mg/kg/day, preferably in 1 dose in the morning (6.00-8.00 AM) or in 2-4 doses
        MEDIUM DOSE:  1-2 mg/kg/day, preferably in 1 dose in the morning (6.00-8.00 AM) or in 2-3 doses

        Maintenance therapy:  0,25 mg/kg/day, in 1 dose in the morning (6.00-8.00 AM)

      • DOSE REDUCTION: If the clinical results are satisfactory, gradually reduce the daily dose and the frequency of administration, starting to eliminate evening dose, than afternoon dose, than any midday dose. The dose is initially decreased in somewhat larger increments to approx. 30 mg/day, than further reduction in smaller increments. The clinical situation will determine the complete reduction of the dose or the need for a a maintenance dose.

Laryngitis subglottica (pseudo-croup)
  • Rectal
    • 1 month up to 2 years
      [1]
      • 100 mg/dose May be repeated once if needed.

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Renal impaiment in children > 3 months

No information available on dose adjustment in renal impairment.

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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here

Side effects

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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here

Contra-indications

No information available on specific contra indications in children.

The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here

Warnings & precautions in children

There is a preference for the use of prednisolone over prednisone due to the (rare) occurrence of a conversion defect (11-beta-hydroxysteroid dehydrogenase reductase ectivity).

Closely monitor growth and development of children with long-term use; to avoid growth inhibition, aim for alternating doses.

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Interactions

The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here

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References

  1. Trommsdorff GmbH & Co., SmPC Rectodelt® 100 mg, Zäpfchen (6329964.00.00), 06/2021
  2. GALENpharma GmbH, SmPC Prednison 5/10/20/50 mg GALEN® Tabletten (33644.00.00), 03/2021

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Changes

Changes