- Dosages
- Side effects in children
- Warnings & precautions in children
- Contra-indications in children
-
Interactions - PK
- Renal impairment
- References
Pharmacokinetics in children
No information is present at this moment.
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dose recommendation of formulary compared to licensed use (on-label versus off-label)
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Available formulations
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Dosages
| Deficiency of vitamin K dependent clotting factors |
|---|
|
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Renal impaiment in children > 3 months
No information available on dose adjustment in renal impairment.
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The complete list of all undesirable drug reactions can be found in the national Summary of Product Characteristics (SmPC) – click here
Side effects
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The complete list of all contra-indications can be found in the national Summary of Product Characteristics (SmPC) – click here
Contra-indications
No information available on specific contra indications in children.
The complete list of all warnings and precautions can be found in the national Summary of Product Characteristics (SmPC) – click here
Warnings & precautions in children
Closely monitoring is indicated due to the risk of thromboembolic events. No data are available on use in perinatal bleeding due to vitamine K deficiency in neonates.
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Interactions
The complete list of all interactions can be found in the national Summary of Product Characteristics (SmPC) – click here
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| Vitamin K | ||
|---|---|---|
| B02BA01 | ||
| Fibrinogen | ||
|---|---|---|
| B02BB01 | ||
| Local hemostatics | ||
|---|---|---|
| B02BC30 | ||
| Blood coagulation factors | ||
|---|---|---|
| B02BD08 | ||
| B02BD04 | ||
| B02BD02 | ||
| Other systemic hemostatics | ||
|---|---|---|
| B02BX05 | ||
| B02BX06 | ||
| B02BX04 | ||
| Blood coagulation factors | ||
|---|---|---|
| B02BD08 | ||
| B02BD04 | ||
| B02BD02 | ||
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References
- Octapharma GmbH, SmPC Octaplex (RVG 30499) 26-08-2019, www.geneesmiddeleninformatiebank.nl
- Peters, M. et al, NVK werkboek kinderhematologie - Stollingsstoornis op basis van Vitamine K deficiëntie, https://hematologienederland.nl/wp-content/uploads/2020/04/KSS-Vitamine-K-deficientie.pdf, 2018
- Prothya Biosolutions Netherlands B.V., SmPC Cofact (RVG 17060) 21-11-2024, www.geneesmiddeleninformatiebank.nl
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Changes
Changes
